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NOVEL NANOEMULSION FORMULATIONS

Technology Benefits

Value PropositionThe delivery system:ΓÇóIs highly customizable as compared to conventional systemsΓÇóComprises an oil in water emulsion for oral, parenteral, ophthalmic, nasal, rectal, or topical delivery of therapeutic/diagnostic agentsΓÇóEffectively delivers broad variety of water insoluble agentsΓÇóHas an almost negligible local or systemic toxicityΓÇóAllows for a higher loading of hydrophobic agents as compared to conventional systemsΓÇóEffectively overcomes biological barrier of organs as compared to conventional systemsΓÇóCan be administered both as a liquid emulsion or as a freeze dried formulationΓÇóWould be commercially useful for delivery of potent drugs such as paclitaxel

Detailed Technology Description

None

*Abstract

Delivery of hydrophobic drugs has always been challenging. In prior art, many approaches have been used in this regard. Some of the most common ones involve the use of co-solvents, surfectants, complexing or solubilising agents, and micellar systems such as liposomes. However, these approaches are associated with potential limitations such as system toxicity in case of surfectants/co-solvents, and lesser stability, low sterility, and low scale commercial production in case of liposomes. Some of the nanoemulsion compositions requiring mechanical pumps have further been used. Such compositions have limited applications with respect to parenteral delivery and blood brain barrier. This approach discloses a novel nanoemulsion based delivery system for efficient delivery of hydrophobic drugs or diagnostic agents.

*Principal Investigator

Name: Mansoor Amiji

Department:

Name: Sandip Tiwari

Department:

Country/Region

USA