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Drawing Collagen Fibers From a Solution of Monomers

Technology Benefits

The procedure:ΓÇóIs highly repeatableΓÇóEffectively allows for a strain directed assembly of collagen fibrilsΓÇóAllows for an assembly of highly organized and aligned collagen fibrilsΓÇóEnables the use of a solution/air interface to generate the required strainΓÇóIs highly customized, enabling change of collagen concentration ranges, magnitude/distribution of strain and the rehydration environmentΓÇóAllows for a fiber drawing rate of 1micron/sec to 1cm/secΓÇóAllows for the concentration of accumulated monomers in the preferred range of 2.4-100 mg/mlΓÇóEnables an adjustment of key process parameters such as temperature, ionic strength, pH and buffersΓÇóWould be commercially useful for various applications such as:o Fabrication of connective tissueso Organized scaffolding for regenerative medicineo Tissue repairo Alignment guide for other molecules such as carbon nanotubes

Detailed Technology Description

None

*Abstract

Drawing Collagen Fibers for a Solution of MonomersDescription:DRAWING COLLAGEN FIBERS FROM A SOLUTION OF MONOMERSINV-13057INVENTORS: Jeffrey Paten, Jeffrey William RubertiLink to PDFDescriptionConventionally, many procedures have been developed and used for assembly of polymeric fibers such as collagen fibrils; however, none of the existing procedures are customized. Moreover, the strain directed assembly of collagen fibrils has never been disclosed earlier. Some of the other limitations associated with existing procedures/techniques are fabrication of unorganized fibrils, non-reproducibility, assembly of small sized fibrils, and reduced efficacy. This approach discloses a novel procedure for fabrication of collagen fibers from a solution of monomers.

*Principal Investigator

Name: Jeffrey Paten

Department:

Name: William Ruberti

Department:

Country/Region

USA