Synthesis and Design of Silver Nanoparticle Embedded mPEG-PDLLA Polymersome Nanocarriers
- Technology Benefits
- The nanocarrier:ΓÇóAllows for combination of multiple drugs into one system, enabling effective treatment of complex infectionsΓÇóProvides a long lasting and time release treatment as compared to conventional systemsΓÇóHelps in effectively overcoming bacterial genetic resistance to antibioticsΓÇóAllows for release of antibiotics over several weeks, reducing the number of dosages as well as infection relapse potentialΓÇóEnables a reduced antibiotic degradation as compared to conventional systemsΓÇóAllows for an ideal particle size, enabling desirable retention time within the biological systemΓÇóWould be commercially useful for the following applications:oTreatment of life-threatening infections especially related to antibiotic resistant bacteriaoReduction in spread of bacterial generic resistance against antibioticsoElimination of persistent infectionsoMedical device/implant coatings for reducing medical device-related infections
- Detailed Technology Description
- None
- *Abstract
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Till date, bacterial genetic resistance to antibiotics has been a major threat to global healthcare management. Infections caused by such bacteria are extremely difficult to treat. Researchers have tried various mechanisms and technologies to overcome this issue; however, none of the existing mechanisms are really effective as they are associated with one or more limitations such as multiple dosage requirements, ineffective treatment (infection relapse) and reduced antibiotic shelf life. This invention relates to the development and use of novel, silver nanoparticles embedded polymersome nanocarriers to effectively target such antibiotic resistant bacteria.
- *Principal Investigator
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Name: Benjamin Geilich
Department:
Name: Thomas Webster
Department:
- Country/Region
- USA
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