Rapid Development of Safer and More Robust Live Attenuated Bacterial Vaccines
- Technology Benefits
- Rapid development of live attenuated bacterial vaccinesMore robust and effective attenuation than current methodsAble to optimize the attenuation to achieve the desirable balance between protection and safety Applicable to a broad range of wild type gram negative pathogenic bacteria
- Technology Application
- Vaccine development for gram negative pathogenic bacteria.
- Detailed Technology Description
- Researchers at Montana State University have discovered a way to simply and easily generate attenuated live bacterial vaccines with controls that allow the attenuation to be optimized. The method consists of promoting the expression of genes that express bacterial cell surface appendages such as flagella that have the capability to attenuate the pathogenic cell. Another step provides for testing the efficacy of the attenuated cell and providing feedback to tightly adjust the attenuation at safely below the level of infection. The ability to easily attenuate and test the attenuation allows rapid generation of candidate vaccines without needing a deep understanding of the pathogenΓÇÖs mechanism of infection or virulence factors.
- *Abstract
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Using a live bacterium to induce immunity to itself has the benefit of mimicking the natural infection and stimulating appropriate and specific antigens to the pathogen. Live vaccines can have the advantage of being able to be administered orally or nasally, and can be easier to manufacture. However, attenuating live bacteria to find the right balance between triggering an immune response or causing an actual infection has been challenging, particularly when immune compromised patients are included in the treated population. Being able to finely tune the attenuation of bacteria to find that balance can be a valuable tool in the development of bacterial vaccines.
- *Principal Investigator
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Name: X Yang, Research Professor
Department: Immunology and Infectious Disease
- Country/Region
- USA
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