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Artificial Cells for Advanced Drug Delivery

Technology Benefits: Main Advantages of this InventionΓÇó Effective delivery of the drug through the biological barriersΓÇó No need to chemically alter the drugΓÇó Administered intravenously

Technology Application: Potential Areas of Application ΓÇó Drug therapeuticsΓÇó Drug development

Detailed Technology Description: None

Supplementary Information: Patent Number: US20140141089A1
Application Number: US2010704416A
Inventor: Liang, Hongjun
Priority Date: 11 Feb 2009
Priority Number: US20140141089A1
Application Date: 11 Feb 2010
Publication Date: 22 May 2014
IPC Current: A61K000914 | A61K0031337 | A61K00314745 | A61K00315415 | A61K00315513 | A61K0031573 | A61K0031635 | A61K003900 | A61K0039395 | A61P000304 | A61P000306 | A61P000310 | A61P000702 | A61P000906 | A61P000910 | A61P000912 | A61P001510 | A61P002508 | A61P002516 | A61P002518 | A61P002522 | A61P002524 | A61P002528 | A61P002702 | A61P002900 | A61P003104 | A61P003110 | A61P003112 | A61P003500
US Class: 424491 | 4241301 | 4241841 | 424498 | 514158 | 514180 | 514221 | 5142232 | 514283 | 514449
Assignee Applicant: Colorado School of Mines,Golden
Title: Nanoparticles, Compositions Thereof, and Methods of Use, and Methods of Making the Same
Usefulness: Nanoparticles, Compositions Thereof, and Methods of Use, and Methods of Making the Same
Summary: In the preparation of pharmaceutical composition for diagnosing and treating a disease or disorder (claimed) selected from breast cancer; prostate cancer; lung cancer; lymphomas; skin cancer; pancreatic cancer; colon cancer; melanoma; ovarian cancer; brain cancer; head and neck cancer; liver cancer; bladder cancer; non-small lung cancer; cervical carcinoma; leukemia; multiple sclerosis, neuroblastoma and glioblastoma; T and B cell mediated autoimmune diseases; inflammatory diseases; infections; hyperproliferative diseases; AIDS; degenerative conditions, cardiovascular diseases, and transplant rejection.
Novelty: Nanoparticle for diagnosing/treating a disease comprises porous framework core with porous framework material and compound; and lipid layer having transmembrane channel configured to release the compound, and is disposed on surface of core

Industry: Disease Diagnostic/Treatment

Sub Category: Cancer/Tumor

*Abstract: This invention uses hybrid artificial cells based on the latest developments in nanotechnology for next-generation drug delivery and solves the problem of crossing a biological barrier to deliver the drugs. The artificial cells will carry therapeutic agents in significant numbers without chemical modification of the individual drug molecules. This is particularly advantageous for drugs that have a narrow therapeutic index and challenging physical characteristics, such as anti-cancer drugs.

*Principal Investigator: Name: Hongjun Liang
Department:

Country/Region: USA

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