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Novel p53-mdm2 and p53-mdm4 antagonists to treat proliferative diseases

Detailed Technology Description
None
*Abstract
Investigators at the University of Pittsburgh have developed small molecules targeting the interaction of p53 protein with both of its binding partners MDM2 and MDM4. This has resulted in a new generation of p53 mdm2 and mdmx antagonists with improved activity and anti cancer profile. Applications:* Treatment for cancer and other proliferative diseasesAdvantages:* Targeting p53 interactions with both of its binding partners MDM2 and MDM4 instead of only MDM2 PCT Patent Application filed
*Principal Investigator

Name: Alexander Doemling

Department: Pharm-Pharmaceutical Science


Name: Tad Holak

Department:

Country/Region
USA

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