Media.Player

Methods for detecting dna originating from different individuals in one sample

Summary

In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate or detect fetal DNA in a maternal sample or to differentiate DNA or an organ donor from DNA of an organ recipient. In preferred embodiments, the DNA species are differentiated by observing epigenetic differences in the DNA species such as differences in DNA methylation. In a second aspect, the present invention features methods of detecting genetic abnormalities in a fetus by detecting fetal DNA in a biological sample obtained from amother. In a third aspect, the present invention features methods for differentiating DNA species originating from an organ donor from those of an organ recipient.; In a fourth aspect, the present invention features kits for differentiating DNA species originating from different individuals in a biological sample.

Supplementary Information

Inventor: LO, YUK MING DENNIS | POON, LIT MAN
Priority Number: CA2456140C
IPC Current: C12Q000168 | G01N003350 | C12M000134 | C12M000140 | C12N001509 | C12P001934
Assignee Applicant: The Chinese University of Hong Kong
Title: METHODS FOR DETECTING DNA ORIGINATING FROM DIFFERENT INDIVIDUALS IN ONE SAMPLE | METHODES DE DETECTION D'ADN PROVENANT DE DIFFERENTS INDIVIDUS
Usefulness: METHODS FOR DETECTING DNA ORIGINATING FROM DIFFERENT INDIVIDUALS IN ONE SAMPLE | METHODES DE DETECTION D'ADN PROVENANT DE DIFFERENTS INDIVIDUS
Summary: The method is useful in detecting DNA originating from different individuals, such as in differentiating or detecting fetal DNA in a maternal sample or differentiating DNA of an organ donor from that of an organ recipient. The method may be used in detecting genetic abnormalities in a fetus.
Novelty: Differentiating DNA species originating from different individuals in a biological sample, useful for detecting genetic abnormalities in a fetus, comprises determining epigenetic differences between these DNA species

Industry

Biomedical

Sub Category

DNA/Gene Engineering

Country/Region

Hong Kong