The present invention provides the use of analogues and derivatives of dinucleoside polyphosphates with formula (I) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in one or more of: the treatment of ischemia, inducing ischemic tolerance, modulating cerebral.....
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Diarylethene-Containing Ligands And Their Coordination Compounds Are Described. The Ligands Display Photochromism With Uv Excitation, While The Coordination Compounds Display Photochromism With Both Excitation In The Uv Region And Excitation Into Lower Energy Absorption Bands Characteristic Of The C.....
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High Throughput And Virtual Screening Methods Are Disclosed That Can Identify Potential Anti-Viral Agents. The Virtual Screening Methods Identify Agents That Interact With A Viral Nucleoprotein Binding Site. The High Throughput Methods Identify Compounds That Inhibit Viral Infection By Binding To Vi.....
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The invention provides compositions comprising fragments of human telomerase reverse transcriptase (hTERT) which can lead to telomere dysfunction in a cell and reduction of growth and tumorigenicity in cancer cells. The invention also relates to uses of the fragments in the treatment of cancer and i.....
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Cell-based and cell-free assays are disclosed that detect compounds that promote aggregation of proteins, glycoproteins, and protein-nucleic acid complexes. Also disclosed are pharmaceutical formulations useful for treating or preventing viral infections, bacterial infections, cancer, and diseases i.....
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