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In recent decades, abundant research data has indicated the existence of cancer stem cells (CSCs), which represent a small, but significant, population among all cells within tumor tissues. These CSCs are mostly responsible for resistance to chemotherapy and radiation therapy, thereby becoming a roo..... [更多]
The anti-CTLA-4 antibody, Ipilimumab, also known as YERVOY, was FDA approved for the treatment of metastatic melanoma in 2011. Ipilimumab works by inhibiting CTLA-4, a protein on T-cells that prevents them from attacking cancer cells. Only about 10-20% of melanoma patients respond to Ipilimumab. Sin..... [更多]
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