Can be used to study the functionof nicotinic acetylcholine receptor subunit functionPotential treatment for centralnervous system disorders Potential treatment and/orpreventative agent for substance use/abuse
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Ability to screen for agents that specifically target downstream components of Hedgehog signaling pathwayAllows identification of agents that modulate Hedgehog pathway activity in a cell
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The inventors describe three different knock-in mice, each with a specific mutation associated with different disease phenotypes relating to cryopyrin associated periodic syndromes: familial cold autoinflammatory syndrome, Muckle Wells Syndrome, and neonatal onset multisystem inflammatory disease. T.....
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