Acute liver failure and chronic liver disease, such as hepatitis and cirrhosis, present a huge unmet medical need, with annual 1-2 million deaths worldwide. The liver is responsible for detoxification-removing and excreting body wastes and hormones, drugs and foreign substances, synthesis of plasma .....
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Female mice are fed with diets rich in specific f.a. (saturated or unsaturated) during pregnancy and/or lactation. The offspring is raised on a regular diet or on a fat rich diet, and develops obesity, fatty liver, and insulin resistance, depending on the diet received in utero. The model allows stu.....
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The present invention relates to an antibody fragment capable of binding to P-glycoprotein associated with multidrug resistant (MDR) cells. The present invention also relates to compositions and methods utilizing such an antibody fragment for inhibiting drug efflux activity in MDR cancer cells.Cance.....
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All heavy machinery relies on large shafts to convey rotary motion. A small shaft crack, if not detected in time, can cause instability which can render the machine unusable and in rare cases even explode. Current methods for locating faults in turbine shafts and generator rotors require either stop.....
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