This invention provides the first evidence that Hsp90 plays an active role in CLL progression/prognosis. Inhibiting Hsp90 or ZAP-70 activity or disrupting the interaction between the two molecules directs otherwise resistant cells to undergo apoptosis. Hsp90 inhibitors (proprietary or those .....
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CA9 SNP pre-screening of patients with RCC prior to IL-2 intervention helps decrease the incidence of unwarranted treatment and the associated adverse side-effects for low-responders Integration of this SNP into various assays by pharmaceutical companies during clinical trials allows for the identi.....
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The cell penetrating peptides (CPPs) identified in this technology are of shorter length and simpler structure than most known CPPs. Due to these characteristics, these CPPs are more cost effective to produce and are effective in penetrating cell membranes to deliver cargo.
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Using a population-based prospective 15 year cardiovascular and stroke risk outcomes the researchers were able to demonstrate the clinical value of oxidation-specific biomarkers as predictors of cardiovascular events and stroke. Individually, one set of markers predicted a higher event rate, whereas.....
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