Treatment of autoimmune conditions such as rheumatoid arthritis, lupus, and diabetes.Treatment of B cell neoplasiasPrevention of tissue rejection
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The method is useful in the therapy of defective, diseased, and damaged neurons in the brain for normal aging or in treating neurodegeneration of the type associated with Alzheimer's disease and Parkinson's.
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Unique chemistry and stability under physiological conditions. Potent compounds active in nanomolar range with an IC50 several fold lower than other apoptosis inhibitors such as pifithrin. Demonstrated efficacy in animal models.
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ΓÇó Reduce cytotoxicity of therapeutic agents by targeting them to specific cells ΓÇó Improved specificity of chemotherapy to cancer cells
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Generalizable to any monoclonal antibody or other recombinant protein biologic therapy Easier than current methods Developed two specific assays, one for rituximab and one for alemtuzumab Phage displayed peptide libraries used to select peptide sequences recogni.....
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