Advantages of ScA include: A bioactive lipopeptide that can directly integrate into lipophilic structures such as liposomes, thus acting a bioactive structural component. This does not require active uptake into the liposome interior, and leaves the interior free for other cargo. Excellent potency,.....
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Unique chemistry and stability under physiological conditions. Potent compounds active in nanomolar range with an IC50 several fold lower than other apoptosis inhibitors such as pifithrin. Demonstrated efficacy in animal models.
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Generalizable to any monoclonal antibody or other recombinant protein biologic therapy Easier than current methods Developed two specific assays, one for rituximab and one for alemtuzumab Phage displayed peptide libraries used to select peptide sequences recogni.....
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Treatment of autoimmune conditions such as rheumatoid arthritis, lupus, and diabetes.Treatment of B cell neoplasiasPrevention of tissue rejection
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This method surpasses previous methods of production, such as using polyvalent proteins and antibodies, which were limited by low throughput and high cost.
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