Methodology is dependent on an enzyme system with broad substrate specificity to ensure homogenous products. High yield with complete regio- and stereo-controlSimplified isolation and purification of desired products. Reactions are carried out in water, which can decrease exposure to otherwise envir.....
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· Reduction in signal background · Functional in physiologically relevantconditions (e.g. cell lysate and intracellularly)
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Through a joint collaboration, the inventorshave synthesized and tested novel non-benzodiazepine GABAA receptorligands functionally selective to the alpha 6 subtype (α6GABAAR).Recent studies have implicated the α6GABAARs as the valid target intrigeminal orofacial pain, neuropsychiatric disorders wit.....
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