This invention describesa new method called SIMPLEx (Solubilization of IMPs with high Levelsof Expression), an in vivosolubilization method of Integral Membrane Proteins (IMPs) in functionallyrelevant conformations without the need for detergents or mutations to the IMPitself.
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This new method is an inside-out vision-based tracking system based on cameras arranged in an orthogonal configuration of two opposing pairs. The arrangement of cameras moves along with the object being tracked, and can be mounted on a mobile platform for use in robotic applications such as tracking.....
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Real-time monitoringMeasurements of multiple cellular mechanical propertiesUse of single-pixel imaging for quantitative dataHigh signal-to-noise ratioFive orders of magnitude higher throughput than state-of-the-art technologies
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Lead Inventors: Wei Gu Ph.D.; JianYuan Luo Ph.D.Problem or Unmet Need:The p53 tumor suppressor exerts anti-proliferative effects, including growth arrest, apoptosis and cell senescence in response to various types of stress. Inactivation of p53 functions has been well documented as a common mechanis.....
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Lead Inventors: Kaushal Shah, MD and Joseph Habboushe, MDProblem or Unmet Need:Despite the need for accurate and precise placement of sutures, physicians currently have no means of marking suture positions that are equidistant from one another. Suture needles that are inserted too far from or too cl.....
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