Improvement of protein production by modulating the tRNA pool. For maximal heterologous expression of proteins per host cell, the optimal level of expression of genes needs to be addressed. The science and art of expressing a gene from one species in another often amounts to modifying the codons of .....
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All heavy machinery relies on large shafts to convey rotary motion. A small shaft crack, if not detected in time, can cause instability which can render the machine unusable and in rare cases even explode. Current methods for locating faults in turbine shafts and generator rotors require either stop.....
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BBS is a monoclonal antibody that binds specifically and blocks beta-secretase (BACE1) cleavage site on its substrate, APP. BBS inhibits Ab production, a hall-mark of AD and other neurodegenerative diseases such as ALS.The mechanism of action of BBS is based on binding of the antibody at the cell s.....
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Improved immunotherapy for breast cancer.Monoclonal antibodies (mAbs) to ErbB-2/HER2 growth factor receptor, or to its sibling, the epidermal growth factor receptor (EGFR), prolong survival of cancer patients, especially when combined with cytotoxic therapies. However, low effectiveness of therapeut.....
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