A universal computational framework for identifying molecular pathways underlying cancer viability and resistance. Our approach is applied to mining large collections of cancer patients’ data and identifying classes of genetic interactions termed synthetic lethality (SL). Synthetic lethality - The d.....
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Background:In low Reynold's number conditions, as in small scales or highly viscous environments, the dynamics are governed mainly by drag effects, therefore mechanisms must rely on non-inertial, non-time reversible trajectories. These conditions are fully satisfied by travelling mechanical waves, o.....
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Background:Stirling cycle-based cryocoolers employ mechanical compressors activated by inductive electrical motors producing an oscillating pressure in a gas. The main disadvantage of these conventional compressors is their limited lifetime, caused by mechanical friction and wear. Wear products degr.....
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Novel genetically modified crops resistant to environmental friendly herbicides.Weeds are considered to be one of the major causes for crop losses by farmers. It is estimated that weeds cause an overall 12% reduction in crop yields or $33 billion in lost crop annually. With the advent of biotechnolo.....
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Although early programs targeting MMPs (matrix metalloproteins) were largely unsuccessful due to adverse side effects, they remain a viable and highly desirable therapeutic target. The main obstacle in the attempts to target MMPs is the ability to selectively target individual family members. The pr.....
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