The invention provides compositions comprising fragments of human telomerase reverse transcriptase (hTERT) which can lead to telomere dysfunction in a cell and reduction of growth and tumorigenicity in cancer cells. The invention also relates to uses of the fragments in the treatment of cancer and i.....
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Cell-based and cell-free assays are disclosed that detect compounds that promote aggregation of proteins, glycoproteins, and protein-nucleic acid complexes. Also disclosed are pharmaceutical formulations useful for treating or preventing viral infections, bacterial infections, cancer, and diseases i.....
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Methods And Compositions For Identifying And Treating Obesity And Obesity-Induced Metabolic Disorders Are Provided. One Aspect Provides A Method For The Evaluation Of Risk And Progression Of Glucose Tolerance, Insulin Resistance And Type 2 Diabetes In Mammalian Subjects. The Method Includes Measurin.....
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