It has been discovered that As.sub.2O.sub.3 suppresses tyrosine kinase receptors, in particular EGFR and IL-6R, by targeting RTKs to lysosomes and/or proteasome for degradation. This is the basis for the discovery that cancers dependent on RTKs for signaling, proliferation, survival, metastasis and .....
[Detail]
The present invention provides compositions comprising multi-, toti- or pluripotent cells and peptides forming a self-assembling peptide nanofiber scaffold that reduces or stops proliferation or differentiation of the cells. The present invention also provides methods for inhibiting cell differentia.....
[Detail]
A novel class of saturated or conjugated dendrimers containing at least one strong .sigma.-donating group coordinated to cyclometalated tridentate gold(III) compounds having the chemical structure depicted by generic formula: ##STR00001## wherein: (a) [Au] is a cyclometalated tridentate gold(III) gr.....
[Detail]
Methods And Compositions For Modulating Cell Differentiation, Proliferation And Morphology In Vitro Or In Vivo Are Described. The Methods Include Modifying The Extracellular Nanoenvironment Of Stem Cells With A Self-Assembling Peptide Nanofiber Scaffold. The Extracellular Nanoenvironment Can Be Modi.....
[Detail]
The Invention Provides N,N'-Disubstituted Monothiourea Or Bis-Thiourea-Pd(0) Complexes That Are Useful As Catalysts For Palladium-Catalyzed Heck Reaction Of Aryl Iodides And Bromides With Olefins, And As Catalysts For Palladium Catalyzed Suzuki Reactions Of Organoboric Compounds And Aryl Halides.
[Detail]
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