Alkylating agents are the most widely used anticancer drugs. Drug resistance is a major obstacle in the successful treatment of cancer by alkylating agents. The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) has been implicated in resistance of human tumors to alkylating agents. .....
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Acute liver failure and chronic liver disease, such as hepatitis and cirrhosis, present a huge unmet medical need, with annual 1-2 million deaths worldwide. The liver is responsible for detoxification-removing and excreting body wastes and hormones, drugs and foreign substances, synthesis of plasma .....
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