A subchondral defect is usually characterized by a structural breakdown of the articular cartilage and the bone underneath due to trauma or disease, leading to chronic disabilities. Treating such defects is an important medical target since in the adult patient, damaged cartilage cannot spontaneousl.....
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The geometry of crystals, bones and other natural objects can appear random. But they possess characteristic patterns which help attain beneficial features, such as aesthetics or structural strength. It is possible to generate such patterns in 2D, using a sample pattern for reference. These methods .....
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A non-invasive diagnostic test to identify individuals with increased risk of lung cancer.Lung cancer is one of the most common cancers and considered to be the leading cause of cancer deaths in the western world, accounting for nearly 30% of all cancer deaths. The high mortality rate is related to .....
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Highlights:p53, the most important tumour suppressor protein in the cell, is a homotetrameric protein that has a pivotal role in the cellular anti cancer defense mechanism.p53 is active as a tetramer: the tetramer binds DNA much tighter than the monomer / dimer and is retained in the nucleus while t.....
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