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Aberrantregulation of FLI1 as well as other transcription factors (eg ERG) areimplicated in several cancers and often result in malignant transformations. Acharacteristic of Ewing Sarcoma involves a chromosomal translocation resultingin a chimeric EWS-FLI1 fusion protein. Mithramycin has been identi..... [Detail]
This invention comprises novel compounds of the Glycosylated Antitumor Ether Lipid (GAEL) class, which selectively target apoptosis-resistant cancer stem cells in ovarian cancer and breast cancer. [Detail]
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