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New Method to Increase the Rate of Protein Ligation Catalyzed by the S. Aureus Sortase A Enzyme
18-fold rate enhancement over other SrtA mediated ligation strategiesSimplifies reaction because fewer components are required as substrate is fused to the enzyme [Detail]
Tags: Other Research Tools Health NanoBio sortase SrtA bioconjugates
New mutant of bacterial cocaine hydrolase with improved stability and catalytic activity against cocaine - 2031
The invention has developed a mutant bacterial cocainehydrolase with an extended half-life (6 hours) at physiological temperatures.This provides therapeutic options for cocaine overdose patients, as well as along-term therapy for cocaine addicts [Detail]
Tags: Drug Abuse; Drug Overdose; Cocaine addiction; cocaine hydrolysis; cocaine metabolism; cocaine toxicity; butyrylcholinesterase
New Resins for Serial Block-Face Scanning Electron Microscopy
University researchers have developed new resins to immobilize tissue samples in Serial Block-face Scanning Electron Microscopy (SBFSEM). The invention has been demonstrated to lead to dramatic improvements in image contrast and resolution for SBFSEM. [Detail]
Tags: materials Scientific/Research Resin serial block-face scanning electron microscopy SBFSEM
New Targets for Chagas Disease Diagnosis and Treatment
Tags: rare/neglected disease Research Tool drug discovery
New Therapeutic Leads for Cachexia and Anorexia
Stimulates feeding for more than six days after a single injectionStimulates feeding longer than all other known hormones/drugs [Detail]
Tags: Cat1 Disease: Women''s Health New Chemical Entities Drug Leads Therapeutics Protein therapeutic gene therapy Health Rehabilitation Disease: Genetic Diseases and Dysmorphic Syndromes cachexia Anorexia Enhanced Mammalian Feeding AgRP body weight stimulates feeding
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