Studying protein-protein interactions in living cells reveals critical information about cell signaling dynamics and cellular mechanisms in both normal and disease conditions. Genetically-encoded fluorescent reporters are ideal for these purposes because they allow non-invasive imaging. However, man.....
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Our scientists have identified a protein‐protein coupling between the glutamate R2 (GluR2) ‐ α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA) receptor and the extracellular protein glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) as a novel target for the treatment of the neurodegenerativ.....
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Extensive pre-clinical work robustly demonstrates combinationEGFR inhibition and methotrexate is supra-additive in potently killing placental tissue.
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Platelet accumulation at sites of vascular injury, even if unintentionally introduced during surgical procedures, is a life-threatening event, for which there are currently no highly-specific treatments. Current drugs dampen platelets or block their ability to form a thrombus, but since they block p.....
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