New target for development of anti-fibrotic drugs
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- Detailed Technology Description
- Anti-IRAP small molecules and prophetic antibodies as anti-fibrotic drugs. A new target for the development of anti-fibrotic medications.
- *Abstract
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Anti-IRAP small molecules and prophetic antibodies as anti-fibrotic drugs. A new target for the development of anti-fibrotic medications that, when inhibited via small molecule reagents in aged mice, completely reverses age-induced cardiac fibrosis. The target is readily 'druggable' by small molecules and could also be inhibited by monoclonal antibodies, thus forming the basis of a development program for creating novel, safe and effective anti-fibrotic drug compositions.
- Country/Region
- USA
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