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Diagnosis of osteoarthritis

總結: First serum biomarker test based on thrombospondin-4 autoantibodies that helps to support the clinical diagnosis of osteoarthritis.

技術應用: The first serum biomarker test that helps to support the clinical diagnosis of osteoarthritis and furthermore may provide a tool that allows the monitoring of therapeutic success of drug candidates for the treatment of arthrosis.

詳細技術說明: Autoantibodies against the cartilage protein thrombospondin 4 (TSP-4) occur in the course of arthrosis. Rheumatoid arthritis is characterized by the presence of autoantibodies, but autoantibodies against TSP-4 have jet not been described for arthrosis. In addition to TSP-4, the researchers have found autoantibodies against the cartilage oligomeric matrix protein (COMP) and the C-type lectin domain family 3 member A (CLEC3A) in the course of OA, which may be used in a combined test together with TSP-4 in order to strengthen significance of diagnosis

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