亞洲知識產權資訊網為知識產權業界提供一個一站式網上交易平台，協助業界發掘知識產權貿易商機，並與環球知識產權業界建立聯繫。無論你是知識產權擁有者正在出售您的知識產權，或是製造商需要購買技術以提高操作效能，又或是知識產權配套服務供應商，你將會從本網站發掘到有用的知識產權貿易資訊。

返回搜索結果

Enzyme-instructed formation of antineoplastic hydrogels

技術優勢: This platform technology improves the safety and efficacy of anti-cancer drugs;Enzyme-instructed self-assembly is a facile strategy for generating the supramolecular hydrogels of molecules that inherently have poor solubility in water;Molecular hydrogels of these hydrophobic drug molecules serve as delivery systems for long term or local delivery of anticancer drugs for chemotherapy;Unlike conventional drug delivery systems, this invention does not require a polymer matrix.

*Abstract: Cancer remains a major challenge to the public health. Therefore, there exists a need for more effective cancer treatments. To improve anti-cancer efficacy and to counteract chemotherapeutic side effects, drug carriers that improve the water solubility of anti-cancer drugs and target tumor cells have been developed. However, conventional drug delivery systems require a polymer matrix, which suffers from degradation and low biocompatibility and low drug capacity.
The current invention overcomes these limitations with nanofibers based on enzyme-triggered self-assembly of small molecules, providing a powerful method to create molecular hydrogels of clinically-used therapeutics without compromising their bioactivities. As both the delivery vehicle and the drug itself (taxol), these molecular nanofibers have tremendous potential as anticancer nanomedicines.

欲了解更多信息，請點擊這裡