亚洲知识产权资讯网为知识产权业界提供一个一站式网上交易平台，协助业界发掘知识产权贸易商机，并与环球知识产权业界建立联系。无论你是知识产权拥有者正在出售您的知识产权，或是制造商需要购买技术以提高操作效能，又或是知识产权配套服务供应商，你将会从本网站发掘到有用的知识产权贸易资讯。

返回搜索结果

Enzyme-instructed formation of antineoplastic hydrogels

技术优势: This platform technology improves the safety and efficacy of anti-cancer drugs;Enzyme-instructed self-assembly is a facile strategy for generating the supramolecular hydrogels of molecules that inherently have poor solubility in water;Molecular hydrogels of these hydrophobic drug molecules serve as delivery systems for long term or local delivery of anticancer drugs for chemotherapy;Unlike conventional drug delivery systems, this invention does not require a polymer matrix.

*Abstract: Cancer remains a major challenge to the public health. Therefore, there exists a need for more effective cancer treatments. To improve anti-cancer efficacy and to counteract chemotherapeutic side effects, drug carriers that improve the water solubility of anti-cancer drugs and target tumor cells have been developed. However, conventional drug delivery systems require a polymer matrix, which suffers from degradation and low biocompatibility and low drug capacity.
The current invention overcomes these limitations with nanofibers based on enzyme-triggered self-assembly of small molecules, providing a powerful method to create molecular hydrogels of clinically-used therapeutics without compromising their bioactivities. As both the delivery vehicle and the drug itself (taxol), these molecular nanofibers have tremendous potential as anticancer nanomedicines.

欲了解更多信息，请点击这里