亞洲知識產權資訊網為知識產權業界提供一個一站式網上交易平台，協助業界發掘知識產權貿易商機，並與環球知識產權業界建立聯繫。無論你是知識產權擁有者正在出售您的知識產權，或是製造商需要購買技術以提高操作效能，又或是知識產權配套服務供應商，你將會從本網站發掘到有用的知識產權貿易資訊。

返回搜索結果

Cloned Zebrafish from Long-Term Cultured Cells

技術優勢: Long-term-cultured cells to provide adequate time for use in targeted genetic manipulation

技術應用: Clone fertile zebrafish from long-term cell cultures to allow for targeted genetic manipulation

詳細技術說明: UCLA researchers have demonstrated the successful cloning of fertile zebrafish from long-term-cultured cells. Transgenic zebrafish are obtained by nuclear transfer using embryonic fibroblast cells from long-term cultures. These transgenic zebrafish will allow the research community to work on targeted genetic manipulation in zebrafish.

*Abstract: UCLA investigators have successfully demonstrated the cloning of transgenic zebrafish from long-term-cultured cells to provide adequate time for use in targeted genetic manipulation. Zebrafish also exhibit characteristics of embryonic stem cells.

*Applications: Clone fertile zebrafish from long-term cell cultures to allow for targeted genetic manipulation

附加資料: Patent Number: US7332647B2
Application Number: US2003517880A
Inventor: Lin, Shuo
Priority Date: 11 Jun 2002
Priority Number: US7332647B2
Application Date: 13 Dec 2004
Publication Date: 19 Feb 2008
IPC Current: A01K0067027 | C12N001500 | C12N0015873
US Class: 800020 | 800024
Assignee Applicant: The Regents of the University of California
Title: Fish produced by nuclear transfer from cultured cells
Usefulness: Fish produced by nuclear transfer from cultured cells
Summary: The methods are useful for making a diploid transgenic fish or a progeny fish (claimed).

其他: State Of Development
Inventors have successfully developed and tested the cloning procedure for transgenic zebrafish from long-term-cultured cells.
Background
Although mammals have been cloned from genetically manipulated cultured cells, there is still a need for lower vertebrates to be used. Since zebrafish are important lower vertebrates to use for the study of vertebrate development, cloned zebrafish may offer an alternative to embryonic stem cells. Zebrafish cell cultures exhibit some characteristics of embryonic stem cells and are easier to use in research involving genetic manipulation. However, only short-term cell cultures of zebrafish exist for the study of vertebrate development.
Related Materials
Lee K, Huang H, Ju B, Yang Z, Lin S. "Cloned zebrafish by nuclear transfer from long-term-cultured cells". Nature Biotechnology. 20, 795-799 (2002)

Tech ID/UC Case
22293/2002-491-0

Related Cases
2002-491-0

欲了解更多信息，請點擊這裡