Enhanced Expression of TRP Channels in Idiopathic Pulmonary Arterial Hypertension (IPAH)
- 詳細技術說明
- The inventors have found that a single nucleotide polymorphism (SNP) in the promoter region of the TRPC6 gene has a higher allele frequency in IPAH patients. This SNP makes the TRPC6 gene susceptible to NF-kappa B. Additionally, it is known that NF-kappa B is activated by inflammation and hypoxia in the lung. This invention teaches that the identified SNP can be used to develop non-invasive tools to predict the diagnosis of IPAH and, further, to develop therapeutic approaches to treat the disease by targeting NF-kappa B-mediated TRPC6 transcription.
- *Abstract
-
Transient receptor potential (TRP) genes code for a family of cation channels in several cell types, including pulmonary artery smooth muscle cells (PASMC). The inventors previously found that two specific isoforms of TRP are significantly upregulated in the PASMC of patients with idiopathic pulmonary arterial hypertension (IPAH) in comparison to normal subjects and patients with hypertension, which is secondary to other cardiopulmonary diseases. Inhibition of TRP expression by siRNA inhibits the growth of PASMC.
- *IP Issue Date
- Jun 21, 2011
- *Principal Investigation
-
Name: Ivana Fantozzi
Department:
Name: Naomi Kunichika
Department:
Name: Judd Landsberg
Department:
Name: Oleksandr Platoshyn
Department:
Name: Carmelle Remillard
Department:
Name: Lewis Rubin
Department:
Name: Patricia Thistlethwaite
Department:
Name: Donna Tigno
Department:
Name: Ying Yu
Department:
Name: Jason Yuan
Department:
- 附加資料
- Patent Number: US7964573B2
Application Number: US2007814038A
Inventor: Remillard, Carmelle | Rubin, Lewis J. | Yu, Ying | Yuan, Jason X.-J.
Priority Date: 14 Jan 2005
Priority Number: US7964573B2
Application Date: 9 Oct 2007
Publication Date: 21 Jun 2011
IPC Current: A01N004304 | A61K003170 | A61K003800 | A61K003900 | A61K003938
US Class: 514044A | 514044 | 4241841 | 5140016 | 514002
Assignee Applicant: The Regents of the University of California
Title: Regulating expression of transient receptor potential channel genes
Usefulness: Regulating expression of transient receptor potential channel genes
Summary: The methods and compositions are useful for predicting a mammalian subject's susceptibility to IPAH, for screening for IPAH in a mammalian subject, and for preventing, diagnosing, and treating IPAH (claimed).
Novelty: Predicting a subject's susceptibility to idiopathic pulmonary arterial hypertension comprises detecting a single nucleotide polymorphism in a sample comprising a TRPC6 gene
- 主要類別
- 診斷/治療
- 細分類別
- 其他疾病
- 申請號碼
- 7964573
- 其他
-
Intellectual Property Info
This technology is patented (#7,964,573; U.S. patent application, published 22-May-2008). Patent claims include a method of treating IPAH in a subject, the method comprising: (a) determining if the subject has a C-254G TRPC6 SNP comprising a G in position – 254 and (b) administering to the subject a therapeutically effective amount of a compound that reduces a biological activity of TRPC6, if the subject has the SNP.
Related Materials
Tech ID/UC Case
19642/2005-073-0
Related Cases
2005-073-0
- 國家/地區
- 美國
