Enhanced Expression of TRP Channels in Idiopathic Pulmonary Arterial Hypertension (IPAH)
The inventors have found that a single nucleotide polymorphism (SNP) in the promoter region of the TRPC6 gene has a higher allele frequency in IPAH patients. This SNP makes the TRPC6 gene susceptible to NF-kappa B. Additionally, it is known that NF-kappa B is activated by inflammation and hypoxia in the lung. This invention teaches that the identified SNP can be used to develop non-invasive tools to predict the diagnosis of IPAH and, further, to develop therapeutic approaches to treat the disease by targeting NF-kappa B-mediated TRPC6 transcription.
Patent Number: US7964573B2
Application Number: US2007814038A
Inventor: Remillard, Carmelle | Rubin, Lewis J. | Yu, Ying | Yuan, Jason X.-J.
Priority Date: 14 Jan 2005
Priority Number: US7964573B2
Application Date: 9 Oct 2007
Publication Date: 21 Jun 2011
IPC Current: A01N004304 | A61K003170 | A61K003800 | A61K003900 | A61K003938
US Class: 514044A | 514044 | 4241841 | 5140016 | 514002
Assignee Applicant: The Regents of the University of California
Title: Regulating expression of transient receptor potential channel genes
Usefulness: Regulating expression of transient receptor potential channel genes
Summary: The methods and compositions are useful for predicting a mammalian subject's susceptibility to IPAH, for screening for IPAH in a mammalian subject, and for preventing, diagnosing, and treating IPAH (claimed).
Novelty: Predicting a subject's susceptibility to idiopathic pulmonary arterial hypertension comprises detecting a single nucleotide polymorphism in a sample comprising a TRPC6 gene
诊断/治疗
其他疾病
7964573
Intellectual Property Info This technology is patented (#7,964,573; U.S. patent application, published 22-May-2008). Patent claims include a method of treating IPAH in a subject, the method comprising: (a) determining if the subject has a C-254G TRPC6 SNP comprising a G in position – 254 and (b) administering to the subject a therapeutically effective amount of a compound that reduces a biological activity of TRPC6, if the subject has the SNP. Related Materials Tech ID/UC Case 19642/2005-073-0 Related Cases 2005-073-0
美国
