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Natural Products for Cancer Therapeutics


詳細技術說明

Although algorithms and chemistries for developing new therapeutic entities are constantly evolving, none can replicate the path and novelty of natural selection over eons of time. Inventors at the Scripps Institution of Oceanography have engaged their fleet of research ships to cull the oceans for marine organisms from which new compositions are isolated.  Using a variety of culture systems, selective fractionation and bioassays, two, distinct classes of compounds, isolated from actinomycetes, have demonstrated potent anti-tumor activity and considerable selectivity toward some cancers. One class of compounds, the ammosamides, are unique molecules that target a previously untargeted intracellular pathway. It is anticipated that proprietary methods and naturally evolved compositions may yield therapeutics that are significantly differentiated from those developed by limited iteration of pre-defined platforms.


附加資料

Patent Number: US8133902B2
Application Number: US2010666269A
Inventor: Fenical, William | Jensen, Paul | MacMillan, John | Hughes, Chambers C. | LaClair, James J.
Priority Date: 29 Jun 2007
Priority Number: US8133902B2
Application Date: 23 Dec 2010
Publication Date: 13 Mar 2012
IPC Current: A61K0031437 | C07D047106
US Class: 514296 | 546081 | 546084
Assignee Applicant: The Regents of the University of California
Title: Ammosamides as anticancer agents
Usefulness: Ammosamides as anticancer agents
Summary: In a pharmaceutical composition; for inhibiting proliferation of mammalian cells; and for treating a mammalian cell proliferative disorder selected from colon cancer (all claimed), head and neck cancer, brain cancer, breast cancer, colorectal cancer, esophageal cancer, gastric cancer, hepatic cancer, bladder cancer, cervical cancer, endometrial cancer, lung cancer, ovarian cancer, gynecological cancers, pancreatic cancer, prostate cancer, renal cancer, lung cancer, skin cancer. Also useful for treating tumor.
Novelty: New ammosamide compound useful in the treatment of cancer e.g. colon cancer, head and neck cancer, brain cancer, breast cancer, colorectal cancer, esophageal cancer, gastric cancer


主要類別

診斷/治療


細分類別

癌症/腫瘤


其他

State Of Development

Potent anticancer activity against HCT-116 (human colon cancer cells).


Intellectual Property Info

Patents pending; see WO/2009/006319.


Related Materials

http://scrippsnews.ucsd.edu/Releases/?releaseID=719
http://fenical.ucsd.edu/Fenical Home.htm
Hughes CC, et. al. Ammosamides A and B target myosin. Angew Chem Int Ed Engl. 2009; 48(4):728-32.
Hughes CC, et al. The ammosamides: structures of cell cycle modulators from a marine-derived Streptomyces species. Angew Chem Int Ed Engl. 2009; 48(4):725-7.


Additional Technologies by these Inventors


Tech ID/UC Case

19544/2006-079-0


Related Cases

2006-079-0, 2010-351-0, 2010-329-0, 2003-248-0


國家/地區

美國

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