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Inhibition of Notch Signaling Reduces the Incidence of Aortic Abdominal Aneurysm

详细技术说明: Abdominal aortic aneurysm (AAA), defined as a localized dilatation of the abdominal aorta, is a life-threatening disease, which has an estimated incidence of 2-4% in the adult population. AAA is chara

*Abstract: Abdominal aortic aneurysm (AAA), defined as a localized dilatation of the abdominal aorta, is a life-threatening disease, which has an estimated incidence of 2-4% in the adult population. AAA is characterized by activation of the inflammatory response causing extensive remodeling of the aortic wall. Researchers at Nationwide Children's Hospital have demonstrated that decreased levels of Notch1 protect against the formation of AAA by preventing macrophage recruitment and down regulating the inflammatory response in the aorta.

*Inquiry: Margaret Barkett, PhD The Research Institute at Nationwide Children's Hospital Office of Technology Commercialization 700 Children's Drive Columbus OH 43205 T: 614 355-2957 F: 614 722-2716 Margaret.Barkett@nationwidechildrens.org

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