Preservation of Eukaryotic Cells using Reversible Pore Formation
- 详细技术说明
- This technology is a method for stabilizing eukaryoticcells, particularly mammalian and human cells, in order to introduce otherwisemembrane impermeable compounds that are helpful for stabilizing the cellsduring drying, chilling, freezing, freeze-drying, or cryopreservation.
- *Abstract
-
The cells are exposed to extracellular ATP (adenosine5'-triphosphate) in concentrations that are sufficient to open pores in theplasma membrane. The otherwise membrane-impermeable compounds that aid insurvivorship of cells are introduced, and after a brief time the pores areclosed. Once the stabilizing compound has been introduced, the cells may bestably preserved and no antigenic compounds need to be introduced.
- *IP Issue Date
- Jan 1, 2008
- *IP Type
- Utility
- *Licensing
- Robert J. BrownAssistant DirectorTel: 225-615-8916Email: rjbrown@lsu.edu
- 国家
- United States
- 申请号码
- 7,314,755
- 国家/地区
- 美国
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