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Methods and Compositions for the Generation of Oocytes and Eggs using Mechanostimulatory Approaches

技术优势

The methods/compositions:ΓÇóEnable differentiation of stem/progenitor cells into oocytes and/or eggsΓÇóCan be applied both ex vivo or in vivo or as a combination to maximize desired outcomesΓÇóProvide a non-invasive procedure to increase oocyte numbers in the ovariesΓÇóAvoid use of potentially harmful pharmacological agents/chemicals for oocyte/egg formationΓÇóProvide novel means for improving fertility outcomes for women seeking pregnanciesΓÇóSignificantly improve quality of life in females, positively impacting millions of women that have no other option for having a genetically matched childΓÇóEffectively enhance or restore female fertile potential and/or prevent, delay or reverse menopause and associated health complicationsΓÇóWould be commercially useful for the following applications:ΓÇóInfertility treatmentΓÇóMenopause related health risk managementΓÇóImprovement of women life qualityΓÇóImprovement of female fertile potential in animal speciesΓÇóImprovement of animal product commercial yieldThe methods/compositions:ΓÇóEnable differentiation of stem/progenitor cells into oocytes and/or eggsΓÇóCan be applied both ex vivo or in vivo or as a combination to maximize desired outcomesΓÇóProvide a non-invasive procedure to increase oocyte numbers in the ovariesΓÇóAvoid use of potentially harmful pharmacological agents/chemicals for oocyte/egg formationΓÇóProvide novel means for improving fertility outcomes for women seeking pregnanciesΓÇóSignificantly improve quality of life in females, positively impacting millions of women that have no other option for having a genetically matched childΓÇóEffectively enhance or restore female fertile potential and/or prevent, delay or reverse menopause and associated health complicationsΓÇóWould be commercially useful for the following applications:ΓÇóInfertility treatmentΓÇóMenopause related health risk managementΓÇóImprovement of women life qualityΓÇóImprovement of female fertile potential in animal speciesΓÇóImprovement of animal product commercial yield

详细技术说明

None

*Abstract

About 7,000,000 couples suffer from infertility in USA; however, only around 150,000 cycles of in vitro fertilization are performed each year. There are several reasons for this large drop-off, including extremely high cost associated with current infertility treatments. In prior art, there are no established methods for inducing cellular (especially stem/progenitor) differentiation using mechano-stimulatory approaches. Moreover, the existing differentiation methods are associated with relatively poor efficiency. This invention relates to novel methods and compositions for generating oocytes and eggs using mechano-stimulatory cellular differentiation approaches.

*Principal Investigation

Name: Murray Gibson

Department:

Name: Jonathan Tilly

Department:

Name: Dori Woods

Department:

国家/地区

美国