NOVEL BIOACTIVE PROTEIN ISOLATED FROM CHINESE YAM AND USES THEREOF
A protein isolated from the Chinese yam Dioscorea opposita that stimulates estrogen and progesterone release in vitro and in vivo but does not stimulate the proliferation of breast and ovarian cancer cells is disclosed. The protein exhibits anti-osteoporotic activity in vivo. Also provided are the procedure for isolation and purification of the protein and the N-terminal amino acid sequence of the protein.
Patent Number: US20130217626A1
Application Number: US13588702A
Inventor: Sze, Cho Wing | Wong, Kam Lok | Tong, Yao | Zhang, Yan Bo | Cheung, Ho Pan
Priority Date: 17 Aug 2011
Priority Number: US20130217626A1
Application Date: 17 Aug 2012
Publication Date: 22 Aug 2013
IPC Current: C07K0014415
US Class: 5140097 | 530300 | 5303879
Assignee Applicant: The University of Hong Kong
Title: Novel Bioactive Protein Isolated From Chinese Yam and Uses Thereof
Usefulness: Novel Bioactive Protein Isolated From Chinese Yam and Uses Thereof
Summary: The bio active peptide is used in composition and medicine for achieving therapeutic effect chosen from increasing serum level of estradiol, estrogen, and/or progesterone, treating osteoporosis and menopausal syndrome in a subject, preferably human at menopause, perimenopause or postmenopause period having menopausal syndrome and osteoporosis, and improving cognitive function and stimulating a splenic mitosis response (all claimed) and chitanase activity and modulating immunity in a subject e.g. female apes, humans, dogs, cats and chickens. The peptide is used in the form of e.g. ingestible tablets, buccal tablets, capsules, elixirs, suspensions, syrups or wafers.
Novelty: New bio active peptide e.g. isolated or substantially pure polypeptide, fragment of polypeptide and variant having sequence identity with polypeptide, used for e.g. increasing serum level of estradiol, estrogen, and/or progesterone
生物医学
医药成分
美国
