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基于ctDNA多位点甲基化的肿瘤病灶位置识别方法

Technology Benefits
可以提高肿瘤病灶位置识别的准确性
Technology Application
肿瘤检测
Detailed Technology Description
本发明涉及医学检测技术,揭露了一种基于ctDNA多位点甲基化的肿瘤病灶位置识别方法及装置,包括:获取ctDNA序列数据,检测ctDNA序列数据的甲基化;生成ctDNA甲基化序列数据对应的高质量ctDNA甲基化序列数据,对高质量ctDNA甲基化序列数据进行序列扩增,得到高质量ctDNA甲基化序列数据簇;确定高质量ctDNA甲基化序列数据簇与目标基因序列组的ctDNA差异序列数据;根据差异权重确定ctDNA差异序列数据中的差异数据频率,根据差异数据频率及差异偏移距离确定差异序列数据中的ctDNA甲基化位点;对ctDNA甲基化位点的变异序列进行检测,根据变异位点识别目标肿瘤的肿瘤病灶位置。本发明可以提高肿瘤病灶位置识别的准确性。
Type of Cooperation
已授权
Application Date
13/04/2023 00:00:00
Application No.
ZL 2023 1 0430384.X
Country/Region
Mainland China

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