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CEACAM1

Summary: CEACAM1 antibodies for anti-viral therapy: immune response against viruses is specific and allows an application to a broad range of viruses.

Technology Benefits: Complementary anti-viral therapy Option
Applies to a broad range of viruses
Specific immune response against specific viruses

Technology Application: therapeutic development

Detailed Technology Description: The approach is based on a antibody-mediated stimulation of the carcino-embryonic antigen-related cell adhesion molecule 1 (CEACAM1), which activates early parts of both the B cell and T cell receptor-induced signal transduction. The researchers have shown on the example of the lymphocytic choriomeningitis virus (LCMV) that these antibodies stimulate the activation and expansion of virus specific cytotoxic T cells, which comes along with a reduced virus load in serum and organs of mice. In vitro studies confirmed efficacy also against influenza virus and cytomegalovirus.

Type of Cooperation: Licensing

Application Date: 28.07.2016

Application No.: US201615221612 20160728

Classes: - international:
C07K16/28; C12N5/0783
- cooperative:
A61K38/177; A61K39/095; A61K39/102; A61K39/1045; C07K16/2803; C12N5/0638; C07K2317/24; C07K2317/565; C07K2317/75; C07K2317/76; C07K2317/92; C07K2319/30; C12N2501/58; Y02A50/466

Others: Patent application

ID No.: 4782

Country/Region: Germany

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