Media.Player

DNA Nanotechnology for Quick and Sensitive Detection of Nucleic Acids in Point-of-Care (POC) Diagnosis Applications

Technology Benefits

CheapSimpleFastCan be done anywhere

Technology Application

Point of care diagnosisDetection of bacteria or virus in water or other solutionsDetection of particular nucleic acids (crime scenes)

Detailed Technology Description

Researchers led by Dino Di Carlo from the Department of Bioengineering at UCLA have developed a quick, cheap, and accurate method to diagnose viral or bacterial infections. Their new method provides the accuracy of cutting edge diagnostic technologies without the cost or complexity. Unlike the expensive, state of the art diagnostic solutions their methodology does not need finely tuned reaction conditions and expensive equipment. Their new diagnostic test can be done at room temperature using a simple mixture and provides accurate diagnoses within 10 minutes. They have done experiments in which they were able to detect influenza RNA with low concentrations at the pico-molar scale (10-12).

Others

Background

Quick, simple, and accurate diagnostics are essential for providing point of care medical services. This allows a physician to collect samples and provide a diagnosis in the same visit as opposed to having to wait days or weeks after coming. The simplicity of a diagnostic test also provides easier access for medical care in underserved areas. Simple conventional diagnostic approaches often suffer from having a high false negative rate, and to increase the accuracy of diagnostic tests require the use of state of the art technologies that have highly complicated protocols along with having high costs. This scenario leaves the patients, especially in underserved areas, without a cheap and accurate means to diagnose diseases.

Additional Technologies by these Inventors

• Sequential Array Cytometry: Multi-Parameter Imaging with a Single Fluorescent Channel
• Sheathless Inertial Cell Ordering Microfluidic Device for Extreme Throughput Flow Cytometry
• Microfluidic Platform to Control Particle Placement and Spacing in Channel Flow
• Single-Molecular Homogenous Amplified Detection in Confined Volumes
• Controllable Emulsification And Point-Of-Care Assays Driven By Magnetic Induced Movement Of The Fluid
• Enhanced Fluorescence Readout And Reduced Inhibition For Nucleic Acid Amplification Tests
• Drop-Carrier Particles For Digital Assays
• Homogenous Entropy-Driven Biomolecular Assay (HEBA)
• Label-Free Digital Bright Field Analysis of DNA Amplification
• Microfluidic Interfacial Magnetic Separation (MIMS)
• Methods For High-Throughput Screening and Sorting of Hyperproducing Single Cells
• Methods And Devices for Continuous Analyte Sensing with Microporous Annealed Particle Gels

Tech ID/UC Case

29419/2017-99I-0

Related Cases

2017-99I-0

*Abstract

Researchers led by Dino Di Carlo from the Department of Bioengineering at UCLA have developed a quick, cheap, and accurate method to diagnose viral or bacterial infections.

*Principal Investigator

Name: Dino Di Carlo

Department:

Name: Donghyuk Kim

Department:

Country/Region

USA