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Multilayered Multifunctional Magnetic Micelle Nanoparticles for DNA Delivery

Technology Benefits
A potential diagnostic and therapeutic agent in TBIDelivers DNA to the brain following mild TBI
Technology Application
theranostic nanoparticles for gene and drug delivery for TBI
Detailed Technology Description
Our researchers have developed and tested multilayered multifunctional magnetic micelle nanoparticles (4MNPs) to deliver DNA to the brain following mild TBI. Their findings have shown that 4MNPs can effectively carry DNA to the brain after mild TBI and this tool can serve as an excellent therapeutic strategy for the delivery of genes or drugs for treatment of TBI. Use of nanoparticle mediated gene delivery techniques hold great potential in brain therapy as they protect the therapeutic gene, allowing for sustained release. Real time monitoring of gene delivery is another advantage to the therapy.
*Abstract
The University of South Florida has developed a novel method for delivering DNA to the brain of rats with mild traumatic brain injury (TBI). This invention can be used as a potential diagnostic and therapeutic agent for humans with the condition.
Country/Region
USA

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