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New Cancer Therapy: RhoB as a Suppressor of Cancer Cell Growth and Transformation

Detailed Technology Description

None

Supplementary Information

Patent Number: US7629310B2
Application Number: US2006512563A
Inventor: Sebti, Said M.
Priority Date: 16 Jun 2000
Priority Number: US7629310B2
Application Date: 30 Aug 2006
Publication Date: 8 Dec 2009
IPC Current: A61K003800 | A61K003816 | A61K003817 | A61K003846 | C07K001400 | C07K001447 | C12N000916 | A61K004800
US Class: 5140011 | 514002 | 435325 | 435366 | 435440 | 5140189 | 5140191 | 530350 | 514021
Assignee Applicant: University of South Florida,Tampa
Title: RhoB as a suppressor of cancer cell growth, cell transformation, and metastasis
Usefulness: RhoB as a suppressor of cancer cell growth, cell transformation, and metastasis
Summary: The method is useful to inhibit growth of a cancerous cell and malignant transformation of a cell, where the cell is a solid tumor cell (claimed). The method is useful to treat e.g. colon and rectum cancer, breast cancer, prostate cancer, urinary cancers, uterine cancers, bladder cancers, oral cancers, pancreatic cancer, melanoma and stomach cancer. The ability of (I) to inhibit cancerous cell was tested in human. The result showed that percentage inhibition of cancerous cell by (I) was 60-80%.
Novelty: Method of inhibiting the growth of a cancerous cell/ inhibiting malignant transformation of a cell comprising contacting the cell with an RhoB protein or its variant

Industry

Disease Diagnostic/Treatment

Sub Category

Cancer/Tumor

*Abstract

Researchers at the University of South Florida have developed a novel cancer therapy using the anti -tumor effect of the RhoB protein to induce cancer cell death.Recent studies have shown that expression of RhoB in human cancer cells leads toinhibition of tumor growth and metastasis as well as induction of cell death. Somestudies suggest that the anti-cancer effects of some current chemotherapeutic agents may be due in part to an alteration of RhoB function in the cancer cell.Our investigators therefore developed a new therapy in which RhoB protein is directly or indirectly administered to cancer cells to inhibit the growth, survival, and metastasis of those cells. This therapy shows great potential as a treatment for a broad spectrum of solid tumors and can also be applied in combination with otheranti-cancer agents.

Country/Region

USA