Gd(III)-nanodiamond conjugates as molecular imaging probes
- Technology Benefits
- 10 times increase in relaxivity, thus, a significant increase in MRI contrast enhancementvery little impact of the hybrid complex on cellular viability, affirming the complex's inherent safety and biocompatibility.
- Detailed Technology Description
- Northwestern researcher have developed a gadolinium(III)-nanodiamond complex that, in a series of tests, demonstrated a significant increase in relaxivity and, in turn, a significant increase in contrast enhancement. #healthcare #imaging #therapeutics #drugdelivery #nanoparticles
- *Abstract
-
Gadolinium (Gd) is the material most commonly used as a magnetic resonance imaging (MRI) contrast agent, but its contrast efficacy can be improved. Nanodiamonds has been demonstrated have excellent biocompatibility and can be used for efficient drug delivery. By coupling the contrast agent to a nanodiamond results in dramatically enhanced signal intensity and thus vivid image contrast. The Gd(III)-nanodiamond complex demonstrated a greater than 10-fold increase in relaxivity -- among the highest per Gd(III) values reported to date. A variety a nanodiamond samples have been imaged, including nanodiamonds decorated with various concentrations of Gd(III), undecorated nanodiamonds and water. The intense signal of the Gd(III)-nanodiamond complex was brightest when the Gd(III) level was highest.
- Country/Region
- USA
