Generation of a New Animal Model for Studying Multiple Sclerosis
There are several advantages the current model offers: shRNA is simple, safe, efficient, and can be delivered to any region of the brainshRNA induces neuro-inflammation and white matter degeneration by mimicking RNA virus infection, but without actual virus pathogens.AAV virus can transduce many different species from rodents to primates, which enables to generate more relevant human MS models in primatesAAV episomal DNA is very stable in mouse brain and maintains expression more than 9 months post-injection. Neuro-inflammation and white matter degeneration in mice were observed several months post-injection.
This new invention provides a more realistic model to use for the development of potentially new and better therapeutic drugs for the treatment of MS.
Researchers at UC San Diego have developed a double-stranded shRNA-induced (scAAV8-D1shRNA virus) neuro-inflammation and white matter degeneration animal model that mimics the pathological conditions of human MS. The dsRNA production can be induced in host cells by either virus infection or via aberrant epigenetic alteration of the host cell genome which may overcome the limitations of the current well-established animal models.
State Of Development This is a research investigational model. Intellectual Property Info A provisional patent has been submitted and is available for licensing. Related Materials Tech ID/UC Case 28805/2017-269-0 Related Cases 2017-269-0
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