Anti-viral drug discovery platform
- Detailed Technology Description
- A novel high throughput screening assay for identifying inhibitors of nuclear import based on a roboticised amplified luminescent proximity homogeneous assay technology.
- *Abstract
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A novel high throughput assay focused on specifically inhibitingnuclear import of viral proteins. The assay has identified a number ofanti-viral drug candidates targeting an evolutionarily conserved (but marketdifferentiated) mechanism of action across numerous viral species.
Proprietary assay to identify potential ‘First in class’ or ‘Best in Disease’ antivirals with a novel and differentiated Mechanism of Action
Specifically targets viral/host protein interface
Proprietary assay to identify potential ‘First in class’ or ‘Best in Disease’ antivirals with a novel and differentiated Mechanism of Action
Applicable to various viral pathogens
Potent exemplar molecules identified including HCV, HIV, dengue virus, West Nile virus, chikungunya virus and Venezuelan Equine Encephalitis virus; expected to be effective for Zika virus.
- Country/Region
- USA
