Monomers to Produce High Molecular Weight Polypeptides Under Mild Conditions
- Detailed Technology Description
- This technology provides a robust method of synthesizing well-defined and diversely structured high molecular weight polypeptides under mild, open-air conditions, an improvement over the classic method of liquid phase peptide synthesis which requires anhydrous conditions and carefully controlled temperature settings.Ring-opening polymerization of interfacial phase amino acid-derived N-thiocarboxyanhydrosulfide (NTA) monomers into a polypeptide is achieved when the monomers are combined with a polymerization initiator. NTAs are significantly less moisture- and temperature-sensitive than the Ν-carboxyanhydrides (NCAs) monomers used in classic peptide synthesis, making this method suitable for laboratories lacking advanced synthetic facilities. Target polymer molecular weight of the resulting polypeptide is achieved by adjusting the ratio of monomer to initiator. This method works quickly
- Countries
- United States
- Application No.
- Patent Pending
- *Abstract
-
Interfacial phase ring-opening polymerizations of α-amino-acid derived N-thiocarboxyanhydrosulfides (NTAs) using soluble primary amine initiators have been demonstrated to produce the corresponding polypeptides in a controlled manner under mild conditions. The NTAs monomers were shown to have significantly enhanced moisture stability relative to their analogous N-carboxyanhydrides (NCA), resulting in long shelf-life and allowing the interfacial phase ring-opening polymerizations to proceed in open air.
- *IP Issue Date
- None
- *IP Type
- Provisional
- Country/Region
- USA
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