AsiaIPEX is a one-stop-shop for players in the IP industry, facilitating IP trade and connection to the IP world. Whether you are a patent owner interested in selling your IP, or a manufacturer looking to buy technologies to upgrade your operation, you will find the portal a useful resource.
Back to search results

Targeting Iron in Colon Cancer via Glycoconjugation of Thiosemicarbazone Prochelators

Detailed Technology Description
Title: Targeting Iron in Colon Cancer Via Glycoconjugation of Thiosemicarbazone Prochelators Invention: The invention is a novel strategy to create iron chelators by utilizing a disulfide redox switch to connect carbohydrate moieties to a thiosemicarbazone iron-binding unit. This increases expression of glucose transporters in colorectal cancer cells and greater toxicity to cancer cells. Background: An increased amount of iron in colorectal cancer cells is a general characteristic of malignancy, and higher expression of glucose transporter is related to poorer prognosis. Iron chelators are currently marred with poor selectivity and resulting systematic toxicity as well as side effects. Applications: Drug companiesBiotechnology companiesDiagnostic assay companies Advantages:Provides a novel pathway for pharmaceutical companies to treat colorectal cancerProvides greater selectivity and toxicity towards target cancer cellsProvides greater water solubility Licensing Manager:Laura SilvaLauraS@tla.arizona.edu(520) 626-1557
*Abstract
None
*Principal Investigator

Name: Elisa Tomat, Assistant Professor

Department: Chemistry & Biochemistry


Name: Eman Akam, Graduate Assistant

Department: Chemistry
Country/Region
USA

For more information, please click Here
Mobile Device