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Tissue Encapsulation with Silica Shell

Summary: Purdue University researchers have developed a method of encapsulating biofilms in a thin, flexible, biocompatible silica membrane. Encapsulated membrane-bound cells are viable, retain their morphology, are metabolically active, and are physically trapped following biosilification. The resultant thin silica membrane is evenly distributed over the biofilm surface, reducing molecular diffusion limitations, and reinforcing the matrix. The technique is scalable and capable of encapsulating complex biofilm geometries by employing endogenous extracellular material as a site for silica deposition. As such, it can potentially be applied to a wide range of cell lines and mixed cellular systems to generate bioreactors for sustained water regeneration and industrial applications.

Technology Benefits: Rapid deployment of bioreactors which contain mature communities of microbesSustainable approach to water recycling option Cell lines retain viability and physiology for over 90 days

Technology Application: Clean Water

Detailed Technology Description: Jenna RickusRickus LaboratoryPurdue Agricultural and Biological Engineering

Countries: United States

Application No.: None

*Abstract

*Background: Water is the most critical element for life support, and water regeneration is essential for establishing base camp self-sufficiency. Water recovery systems currently under development are intensive users of resources. Portable, rapidly deployable, low input systems are needed to maximize the logistical savings provided by water recycling. A strategy that relies on the integration of biological systems for regenerative oxidation of wastewater contaminants is needed. Microbiological reactors are innately more regenerative than physiochemical systems. Adsorbents or catalysts with limited life spans are replaced by living cells that "recycle" the energy harnessed from oxidative reactions to carry out the reductive processes necessary for cell maintenance and growth.

*IP Issue Date: None

*IP Type: Continuation

*Stage of Development: Proof of Concept

*Web Links: Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipJenna RickusRickus LaboratoryPurdue Agricultural and Biological Engineering

Country/Region: USA

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