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Discriminating Naive Human Pluripotency

Technology Benefits
Non-invasive: cells are undestroyed during characterizationHigh sensitivity: detection at the single-cell level
Technology Application
Research tool to characterize stem cell differentiationMolecular characterization of media developed to revert stem cells to naïve state
Detailed Technology Description
UCLA Researchers have developed a simple, non-invasive molecular approach to identify and separate naïve cells at the single-cell level from those that are in the primed state.
Application No.

State Of Development

In vitro demonstration


Human pluripotent stem cells were first made under what is called “primed” conditions, creating a cell type that is primed for differentiation. This has led to the search for media formulations that can revert the pluripotent stem cell lines to the so-called naïve state, which is hypothesized to be closer in identity to the true pluripotent stem cells found in the body or embryo. As research grows in this field to generate media combinations to revert primed human stem cells to the naïve state, there is a corresponding need to identify naïve cells from primed cells. Currently, the only molecular approach for assessing naïve pluripotency is through RNA-Seq, which requires the destruction of cells.

Related Materials

Pastor, William A. et al. Cell Stem Cell, Volume 18 , Issue 3 , 323 - 329

Additional Technologies by these Inventors

Tech ID/UC Case


Related Cases


UCLA Researchers in the Department of Molecular, Cell, and Developmental Biology have developed a simple molecular approach to non-invasively distinguish and isolate human pluripotent stem cells that have reverted from the primed pluripotent state to the native state.
*IP Issue Date
Aug 10, 2017
*Principal Investigator

Name: Di Chen


Name: Amander Clark



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