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Catalytic Coupling Reactions Using Frameworks with Open-Metal-Sites

Technology Benefits

• Copper-based catalyst• Catalysts are easily produced• High chemical and temperature stability

Technology Application

• Coupling-reaction catalyst• Drug Precursor Synthesis

Detailed Technology Description

Dr. Omar Yaghi and colleagues at UCLA have developed a copper (Cu)-based metal organic framework and metal organic polyhedra that can be used as a catalyst in a homo-coupling synthesis reaction to generate biaryls. The catalyst was demonstrated to have up to 95% conversion and 90% selectivity as well as having high chemical stability.

Application No.

9045387

Others

State Of Development

A series of Suzuki homo-coupling and Chan-Lam coupling reactions have been successfully performed using various MOFs and MOPs. 

Background

Coupling reactions are used in organic chemistry to join two hydrocarbons. Because of the importance of hydrocarbons, coupling reactions are widely utilized in the pharmaceutical industry as well as in industrial chemistry. In coupling reactions, a metal catalyst such as Palladium (Pd) is traditionally used. Other traditionally used catalyst include Cr (II), Pb (II), Mn (IV), Ti (II), and Ni (II). Problems using these metal catalysts include poor yields, poor selectivity, environmentally-unfriendly, and restricted operating conditions. A better catalytic system for coupling reactions will be highly beneficial to both the pharmaceutical and industrial industry by improving material economy and minimizing environmental toxicity.

Additional Technologies by these Inventors

• Carbon Dioxide Capture and Storage Using Open Frameworks
• Metallation of Open Frameworks
• BORGS: Beyond Open Reticulated Geometries
• Conductive Open Frameworks
• Multi-Dimensional Networks
• Adsorptive Gas Separation of Carbon Dioxide from Methane by Zeolitic Imidazolate Frameworks (ZIFs)
• Reversible Hydrogen Storage Using Metal-Organic Frameworks (MOFs)
• Reversible Ethylene Oxide Capture in Metal Organic Frameworks (MOFs)
• Design and Synthesis of New Metal-Organic Frameworks (MOFs) With Unique Topologies
• Oxidative CH Activation of Non-Activated Alkanes Using Metal-Organic Frameworks (MOFs) as Catalysts

Tech ID/UC Case

25267/2009-757-0

Related Cases

2009-757-0

*Abstract

UCLA researchers in the Department of Chemistry and Biochemistry have developed a group of novel organic framework-based catalysts used in coupling reactions. These catalysts demonstrate high efficiency and specificity, combined with the great chemical stability and reproducibility seen with organic framework materials.

*IP Issue Date

Jun 2, 2015

*Principal Investigator

Name: Zheng Lu

Department:

Name: Bo Wang

Department:

Name: Omar Yaghi

Department:

Name: Alexander Czaja

Department:

Country/Region

USA