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Dual Transgenic Mice for Endothelial Cell Research (Ve-Cadherin Cre-Recombinase - Rosa26r-YFP)

Technology Benefits: Endothelial-specific gene recombination ensures that only endothelial cells are labeled with YFP

Technology Application: Use as a model system to investigate endothelial gene expression in the context of either physiological or pathological conditions

Detailed Technology Description: UCLA researchers have developed a dual transgenic animal that enables genetic tracing of endothelial cells and their derivatives. Specifically, endothelial cells are labeled with YFP, and an endothelial-specific promoter drives Cre-recombinase (VE-Cadherin).

Others

State Of Development

The mouse model has been developed, validated, and communicated to the scientific community.

Background

Disturbances in endothelial gene expression contribute to vascular morphogenesis and tumor growth. Over the past century, the mouse has emerged as the premier mammalian model system for genetic research. Its genetic and physiological similarities to humans, as well as the ease with which its genome can be manipulated, make it especially attractive as models for human disease. Thus, mouse models that enable genetic tracing of endothelial cells would be of great use to vascular biologists.

Additional Technologies by these Inventors

Tech ID/UC Case

22805/2011-725-0

Related Cases

2011-725-0

*Abstract: UCLA researchers have developed a dual transgenic animal that enables genetic tracing of endothelial cells and their derivatives.

*Applications: Use as a model system to investigate endothelial gene expression in the context of either physiological or pathological conditions

*Principal Investigator: Name: Luisa Iruela-Arispe
Department:

Country/Region: USA

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