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Induced Pluripotent Stem Cell Lines and Method to Generate Human Embryonic Stem Cells from Dermal Fibroblasts

Technology Benefits: Create custom-made human embryonic stem cell-like cells (iPS) to target individual degenerative diseases Avoid immunological rejection Avoid technical and ethical considerations raised by the generation of stem cells from human embryos

Technology Application: Create human embryonic stem cell-like cells (iPS cells) from human skin fibroblasts (research tool) Generate custom-made human embryonic stem cell-like cells (iPS cells) from any person to ameliorate degenerative diseases (therapeutic) Utilize currently available human iPS cell lines to study differentiation into various tissue specific lineages

Detailed Technology Description: UCLA researchers have developed a method to generate human iPS cells from human dermal fibroblasts. Researchers were able to reprogram human somatic cells by overexpressing transcription factors in human skin fibroblasts to induce pluripotency. These cells can, just like ES cells, be differentiated into cells of all three germ layers. The method can also be used to create custom-made human embryonic stem cells from any person. For people with degenerative diseases, human iPS cells can be generated and differentiated, and then transplanted back in the same person to avoid immunological rejection. Researchers have generated multiple human induced pluripotent stem cell lines that can be used to study their differentiation potential.

Supplementary Information: Patent Number: US20100285589A1
Application Number: US2010743776A
Inventor: Lowry, William E. | Plath, Kathrin
Priority Date: 19 Nov 2007
Priority Number: US20100285589A1
Application Date: 23 Jul 2010
Publication Date: 11 Nov 2010
IPC Current: C12N0015867 | C12N0005074 | C12N00050793 | C12N000510
US Class: 435455 | 4353201 | 435366
Assignee Applicant: The Regents of the University of California
Title: GENERATION OF PLURIPOTENT CELLS FROM FIBROBLASTS
Usefulness: GENERATION OF PLURIPOTENT CELLS FROM FIBROBLASTS
Summary: The methods are useful for: preparing an enriched population of de-differentiated/induced stem cells; de-differentiating a human somatic cell, which is a fibroblast cell (preferably dermal fibroblasts) or stromal cells; and regenerating human cells, tissues (skin tissue) and/or organs damaged by injury or disease. The vector system is useful for producing human stem cells (all claimed). The stem cells are useful in transplantation, tissue engineering, regulation of angiogenesis, vasculogenesis, and cell replacement or cell therapies as well as the prevention of e.g. degenerative diseases, pathological disease resulting from cancers, neoplasms, injury, viral infections, diabetes, vascular diseases, and motor neuron diseases. The human induced pluripotent stem cells and their progeny is useful in the treatment of tissue damage and repair. The stem cells are useful to introduce a gene into a subject (preferably human). No biological data given.
Novelty: Preparing enriched population of de-differentiated/induced stem cells comprises contacting human somatic cell with retroviral vector, culturing the somatic cell, selecting cells that express a tumor rejection antigen and subculturing

Industry: Biomedical

Sub Category: Bioengineering

Application No.: 9005966

Others

State of Development

Investigators have successfully demonstrated the ability to generate human embryonic stem cell-like cells (iPS cells) from dermal fibroblasts. They are still testing the concept of generating custom-made human embryonic stem cells to treat degenerative diseases and avoid immunological rejection through transplantation.

Background

The use of stem cells to treat a variety of degenerative diseases has been a promising area of research and treatment. However, the therapeutic use of stem cells depends on the availability of pluripotent cells that are not limited by technical, ethical, or immunological considerations. There have been research groups, including one at UCLA, that generated mouse iPS cells from fibroblast and demonstrated that these cells are functionally and molecularly virtually identical to embryonic stem cells. However, there is a need to generate human embryonic stem cells with human fibroblasts.

Related Materials

Generation of human induced pluripotent stem cells from dermal fibroblasts. PNAS. 2008

Additional Technologies by these Inventors

Tech ID/UC Case

20400/2008-246-0

Related Cases

2008-246-0

*Abstract: UCLA investigators have developed a method to generate human embryonic stem cell-like cells from human skin fibroblasts. These so-called induced pluripotent stem (iPS) cells have tremendous potential to create custom-made human embryonic stem cells to treat individuals with degenerative diseases.

*IP Issue Date: Apr 14, 2015

*Principal Investigator: Name: William Lowry
Department:

Name: Kathrin Plath
Department:

Country/Region: USA

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